Internet of things (IoT), robotics, and artificial intelligence (AI) hold the key to Industry 4.0. To stay relevant in the AI age, humans must collaborate and/or even merge with electronics, machines and robots to realize internet of health (IoH), augmented reality (AR), as well as augmented human capabilities. However, bio-tissues are soft, curvilinear and dynamic whereas conventional electronics and machines are hard, planar, and rigid. Over the past decade, soft electronics blossom as a result of new materials, novel structural designs, and digital manufacturing processes. This talk will discuss our research on the design, fabrication, conformability, and functionality of soft bio-integrated and bio-mimetic electronics based on inorganic functional materials such as metals, silicon, carbon nanotubes (CNT), and graphene. In particular, epidermal electronics, a.k.a. electronic tattoos (e-tattoos) represent a class of noninvasive stretchable circuits, sensors, and stimulators that are ultrathin, ultrasoft and skin-conformable. My group has invented a dry and freeform “cut-solder-paste” method for the rapid prototyping of multimodal, wireless, or very large area e-tattoos that are also high-performance and long-term wearable. The e-tattoos can be applied for physiological sensing, prosthesis control, and human-mimetic robots. Examples could range from human-robot interaction to implantable artificial retina. A perspective on future opportunities and challenges in this field will be offered at the end of the talk.